The authors of a follow-up study (published in 2021) investigated the possible benefits of TPS® treatment concerning brain morphology, namely the cortical atrophy characteristic of Alzheimer’s disease . They found a significant correlation between neuropsychological improvement and cortical thickness increase in AD-critical brain areas.
AD patients who benefit from TPS® appear to manifest reduced cortical atrophy within the default mode network in particular, whose memory-related subsystems are believed to be disrupted in AD. This was found for the left precuneus and the superior parietal lobule.
 Popescu T, Pernet C, Beisteiner R. Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer’s patients: A follow-up study. Alzheimer’s Dement. 2021;7:e12121. https://doi.org/10.1002/trc2.12121
(Read the full paper here: https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/trc2.12121)